Abstract
Magnesium phosphate cements (MPC) have been demonstrated to have a superior bone regeneration capacity due to their good solubility under in vivo conditions. While in the past only aqueous MPC pastes have been applied, the current study describes the fabrication and in vitro/in vivo testing of an oil-based calcium doped magnesium phosphate (CaMgP) cement paste. Premixed oil-based pastes with CaMgP chemistry combine the advantages of conventional MPC such as high mechanical strength and good resorbability with a prolonged shelf-life and an easier clinical handling. The pastes set in an aqueous environment and predominantly form struvite and achieve a compressive strength of ~8–10 MPa after setting. The implantation into a drill-hole defect at the distal femoral condyle of New Zealand white rabbits over a course of 6 and 12 weeks demonstrated good biocompatibility of the materials without the formation of soft connective tissue or any signs of inflammation. In contrast to a hydroxyapatite forming reference paste, the premixed CaMgP pastes showed subsequent degradation and bony regeneration. The CaMgP cement pastes presented herein are promising bone replacement materials with excellent material properties for an improved and facilitated clinical application.
Highlights
Magnesium phosphate minerals such as struvite (MgNH4 PO4 ·6H2 O) [1] or newberyite (MgHPO4 ·3H2 O) are currently discussed to be suitable alternatives to calcium phosphate phases for application as bone replacement materials [2]
The reaction aqueous solution in the static mixer of the double chamber cartridge and resulted in the of the calcium doped magnesium phosphate (CaMgP) powders with the ammonium phosphate in the paste was initiated by mixing with the predominant formation of struvite (MgNH4PO4·6H2O) and a minor fraction of newberyite aqueous solution in the static mixer of the double chamber cartridge and resulted in the predominant (MgHPO4·3H2O)
The current study describes the characterization of premixed calcium doped magnesium phosphate cement pastes with improved degradation properties under in vitro and in vivo conditions
Summary
Magnesium phosphate minerals such as struvite (MgNH4 PO4 ·6H2 O) [1] or newberyite (MgHPO4 ·3H2 O) are currently discussed to be suitable alternatives to calcium phosphate phases for application as bone replacement materials [2] This assumption is based on the higher solubility and biocompatibility of MgP minerals under in vivo conditions [3], which should lead to faster resorption and bone remodeling stimulated by released magnesium ions [4]. Since most of the implanted magnesium phosphate minerals are hydrated species, their processing and in vivo application usually follows a cementitious route, in which the starting minerals are mixed with an aqueous solution to form a paste The latter shows a cementitious reaction due to the lower solubility of cement raw materials and the setting product and leads to the formation of a mechanically stable implant.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
