Development and Application of MAGIC-f Gel in Cancer Research and Medical Imaging

Rabin Dhakal,Mohammad Yosofvand,Hanna Moussa

doi:10.3390/app11177783

Abstract

Much of the complex medical physics work requires radiation dose delivery, which requires dosimeters to accurately measure complex three-dimensional dose distribution with good spatial resolution. MAGIC-f polymer gel is one of the emerging new dosimeters widely used in medical physics research. The purpose of this study was to present an overview of polymer gel dosimetry, using MAGIC-f gel, including its composition, manufacture, imaging, calibration, and application to medical physics research. In this review, the history of polymer gel development is presented, along with the applications so far. Moreover, the most important experiments/applications of MAGIC-f polymer gel are discussed to illustrate the behavior of gel on different conditions of irradiation, imaging, and manufacturing techniques. Finally, various future works are suggested based on the past and present works on MAGIC-f gel and polymer gel in general, with the hope that these bits of knowledge can provide important clues for future research on MAGIC-f gel as a dosimeter.

Highlights

Gel dosimeters are composed of radiation-sensitive chemicals that experience a fundamental change in their properties following ionizing radiation, due to the absorbed dose [1,2]
The MAGIC-f gel is analyzed by using the same diagnostic imaging techniques as other polymer gels, such as optical computer tomography (OCT), X-ray CT [12,44,45,46], magnetic resonance imaging (MRI) [3,27,47,48], and ultrasound [49,50,51]
Out of these techniques OCT and MRI are most popular based on the physical change occurring in gel due to irradiation [52]

Summary

Introduction

Gel dosimeters are composed of radiation-sensitive chemicals that experience a fundamental change in their properties following ionizing radiation, due to the absorbed dose [1,2] These features of the polymeric gel dosimeters can store dose distribution information in three dimensions, an additional benefit compared to other dosimeters that provide only one-dimensional dose distribution, such as ionization chambers and films in a point, or two-dimensional dose distribution [2,3]. This benefit is especially important for emerging technologies relating to radiation, where there is a substantial incidence of highdose gradients [4]. These polymer gels are usually analyzed by using various diagnostic imaging techniques, such as sonography, optical computer tomography (OCT), X-ray computer tomography (X-ray CT), and magnetic resonance imaging (MRI) [5].

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Conclusion