Abstract
Bioassay systems have been widely applied in large-scale screening of dioxins. Among these systems, the luciferase reporter gene-based bioassay system is designed based on aryl hydrocarbon receptor signaling pathway which mediates a series of toxicological effects of dioxins. The advantages of this bioassay system include high sensitivity, wide application and strong correlation with toxicological effects. Based on recent research on several newly developed systems, the minimum detection limit of such analytical method can reach 0.1 pM. This system could be widely used in agricultural, food, environmental, government administration and the third party inspection agency. Furthermore, a broad application prospect of this bioassay system has been proposed recently in environmental health study and health risk assessment. This review describes the development, application, standardized methods and mechanism of CALUX assay, as well as the future perspective.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
