Abstract
vTwo simple, rapid, precise and reproducible UV spectroscopic methods has been developed for simultaneous estimation of two component drug mixture of doxofylline (DOX) and ambroxol hydrochloride (AMB HCL) in bulk and combined tablet dosage form. First method employs simultaneous equation method using 274nm (λ max of DOX) and 247nm (λ max of AMB) as two wavelengths for estimation. The second method involves Q-Absorption ratio method the wavelength used were 274nm (λ max of DOX) and 255nm (isoabsoptive point). For the two methods methanol was used as solvent. Linearity was observed in the concentration range of 5-30 µg/ml for DOX and 2-6 µg/ml for AMB HCL. The percentage recovery was found in the range of 98.92- 101.25 for doxofylline and 98.75-100.83 for ambroxol hydrochloride. The developed method was validated statistically and by recovery studies. The % RSD value was found to be less than 2. Thus the proposed method was simple, precise, economic, rapid and accurate and can be successfully applied for simultaneous determination of doxofylline and ambroxol hydrochloride in bulk and combined tablet dosage form. © 2011 IGJPS. All rights reserved.
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