Abstract
Collagen is the most widespread extracellular matrix (ECM) protein in the body and is important in maintaining the functionality of organs and tissues. Studies have explored interventions using collagen-targeting tissue engineered techniques, using collagen hybridizing or collagen binding peptides, to target or treat dysregulated or injured collagen in developmental defects, injuries, and diseases. Researchers have used collagen-targeting peptides to deliver growth factors, drugs, and genetic materials, to develop bioactive surfaces, and to detect the distribution and status of collagen. All of these approaches have been used for various regenerative medicine applications, including neovascularization, wound healing, and tissue regeneration. In this review, we describe in depth the collagen-targeting approaches for regenerative therapeutics and compare the benefits of using the different molecules for various present and future applications.
Highlights
Collagen, the most abundant extracellular matrix (ECM) protein in mammals, regulates numerous bodily processes, from the molecular to the macroscopic scale [1]
Collagens are a key component of the extracellular matrix in most tissues and can be a main identifier of diseased tissue when dysregulated
Though extensive research has worked on targeting collagen for regenerative and therapeutic efforts, this field has not been thoroughly exhausted in its applicability
Summary
The most abundant extracellular matrix (ECM) protein in mammals, regulates numerous bodily processes, from the molecular to the macroscopic scale [1]. It plays a large role in dictating the overall mechanical and metabolic properties of tissues [1]. In many cases of developmental defects, injuries, and diseases, collagen is observed to be injured or dysregulated [2]. We further describe collagen’s structure-function relationship and its role in developmental defects, injury, and disease. We introduce the collagen-targeting molecules used to date and the recent advances in their therapeutic and regenerative application
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