Abstract
A pure compound has been isolated and identified as coptisine on the basis of UV and NMR spectroscopy data using preparative separation of the extract from greater celandine (Chelidonium majus L.) herbs by column chromatography over short columns of silica gel. Qualitative and quantitative estimation of the total alkaloid contents in C. majus is performed using TLC analysis and spectrophotometry (analytical wavelength 360 nm). The need for using a state standard sample of coptisine is validated. The total content of alkaloids in C. majus herbs varies within 0.90-1.75% (calculated as coptisine). The relative error of the determination of the total alkaloid content using the proposed method at a confidence probability of 0.95 does not exceed ±4.40%.
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