Developing dietary fiber moringa gum based ciprofloxacin encapsulated hydrogel wound dressings for better wound care

Abstract

Keeping in view inherent wound healing potential of moringa gum (MG), in present research, it has been applied in development of hydrogel wound dressings encapsulated with antibiotic drug ciprofloxacin for better wound care .The copolymeric hydrogels were characterized by SEMs, AFM, FTIR, XRD, 13C NMR, TGA and DSC. SEM, AFM and XRD demonstrated porous morphology with rough surface having amorphous state of copolymers. Hydrogel dressings absorbed 7.71± 0.06 g/g simulated wound fluid to maintain moist wound surrounding. The diffusion of ciprofloxacin was non Fickian type from copolymer. They also exhibited mucoadhesive (3.15 ± 0.67 N s work of adhesion) and antioxidant (91.44 ± 2.89% scavenging in DPPH assay) properties. Dressings were permeable to H2O, O2 and impermeable to microbes. These characteristic properties of hydrogel dressings revealed that dietary fiber moringa gum could be applied as wound dressing materials for better wound health.