Developing central diabetes insipidus following neurohypophysitis during the convalescent period after recovering from covid-19: presentation of a clinical case and literature review

Abstract

Currently, there is a substantial body of research dedicated to exploring the impact of SARS-CoV-2 on the endocrine system. However, information regarding pathological changes in the hypothalamo-pituitary system in the context of COVID-19 remains limited. Hypophysitis is a general term encompassing various inflammatory conditions affecting the pituitary gland, leading to structural alterations in the hypothalamo-pituitary axis and various levels of hormonal deficiencies in the anterior and/or posterior pituitary.This paper presents a clinical case of central diabetes insipidus resulting from neurohypophysitis, manifested two months after recovering from the novel coronavirus infection SARS-CoV-2 (COVID-19). Our study contributes to expanding knowledge about a rare but potentially consequential outcome of the novel coronavirus infection, which holds significance given the global prevalence of COVID-19. The unexpected consequences of SARS-CoV-2 infection contribute to maintaining caution among medical professionals and stimulate interest in scientific research.