Developing an Improved Survival Prediction Model for Disease Prognosis.

Abstract

Machine learning has become an important research field in genetics and molecular biology. Survival analysis using machine learning can provide an important computed-aid clinical research scheme for evaluating tumor treatment options. However, the genomic features are high-dimensional, which limits the prediction performance of the survival learning model. Therefore, in this paper, we propose an improved survival prediction model using a deep forest and self-supervised learning. It uses a deep survival forest to perform adaptive learning of high-dimensional genomic data and ensure robustness. In addition, self-supervised learning, as a semi-supervised learning style, is designed to utilize unlabeled samples to improve model performance. Based on four cancer datasets from The Cancer Genome Atlas (TCGA), the experimental results show that our proposed method outperforms four advanced survival analysis methods in terms of the C-index and brier score. The developed prediction model will help doctors rethink patient characteristics' relevance to survival time and personalize treatment decisions.