Developing a vaccine against Marburg virus disease

Abstract

Marburg virus disease is a severe infection in people and non-human primates (NHPs), with a case-fatality rate of 23–90%. 1 Centers for Disease Control and PreventionMarburg (Marburg Virus Disease). https://www.cdc.gov/vhf/marburg/index.htmlDate: 2022 Date accessed: November 23, 2022 Google Scholar The disease is caused by the Marburg virus, a member of the Filoviridae family, which includes the viruses responsible for Ebola virus disease. 1 Centers for Disease Control and PreventionMarburg (Marburg Virus Disease). https://www.cdc.gov/vhf/marburg/index.htmlDate: 2022 Date accessed: November 23, 2022 Google Scholar Marburg virus disease is extremely rare. Since its discovery in 1967, when two outbreaks occurred simultaneously in laboratories in Marburg and Frankfurt in Germany, and in Belgrade, Yugoslavia (now Serbia), causing 31 cases and seven deaths, there have been 16 known outbreaks with a cumulative total of fewer than 500 reported cases. 2 Centers for Disease Control and PreventionHistory of MVD outbreaks. https://www.cdc.gov/vhf/marburg/outbreaks/chronology.htmlDate: 2022 Date accessed: November 23, 2022 Google Scholar , 3 WHOMarburg virus—Ghana. https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON409Date: 2022 Date accessed: November 23, 2022 Google Scholar Safety, tolerability, and immunogenicity of the chimpanzee adenovirus type 3-vectored Marburg virus (cAd3-Marburg) vaccine in healthy adults in the USA: a first-in-human, phase 1, open-label, dose-escalation trialThis first-in-human trial of this cAd3-Marburg vaccine showed the agent is safe and immunogenic, with a safety profile similar to previously tested cAd3-vectored filovirus vaccines. 95% of participants produced a glycoprotein-specific antibody response at 4 weeks after a single vaccination, which remained in 70% of participants at 48 weeks. These findings represent a crucial step in the development of a vaccine for emergency deployment against a re-emerging pathogen that has recently expanded its reach to new regions. Full-Text PDF