Abstract
Combinatorial therapy is highly recommended for treating age-linked dysfunctions since multiple organs and biological targets are simultaneously affected. Ayurveda employs a holistic treatment strategy where drug combinations of higher therapeutic potential is utilized as a treatment regimen. Rasayanas are one of the most commonly used formulation in Ayurveda. Narasimha Rasayana is a predominant formulation in Ayurveda reported for bringing out anti-aging and rejuvenation effects. However, the mechanism of action of Narasimha Rasayana is least studied due to its complexity in terms of large number of bioactive ingredients present. The objective of current study is to elucidate the molecular mechanism of action of bioactive components present in Narasimha Rasayana. Systems pharmacology approach was employed for the elucidation of molecular mechanism of bioactive components present in Narasimha Rasayana. The target genes, interacting partners, diseases transcription factors and pathways associated with bioactive components were explored to understand the molecular mechanism. Systems pharmacology studies concluded the interactions of bioactive components with key molecular components of pathways reported for aging. We have identified the interaction of bioactive components present in Narasimha Rasayana with key biomarkers involved in aging pathways such as mTOR and insulin signalling pathways. The bioactive components such as gallic acid, epicathechin, plumbagin, gallic acid, ellagic acid, quercetin and genistein were found to interact with components of PI3K/AKT signalling pathway, insulin signalling pathway and mTOR signalling pathway via FOXO transcription factors.
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