Developing a Model to Simulate the Effect of Hypothermia on Cerebral Blood Flow and Metabolism.

Joshua Russell-Buckland,Ilias Tachtsidis

doi:10.1007/978-3-030-34461-0_38

Joshua Russell-Buckland, Ilias Tachtsidis

Open Access

https://doi.org/10.1007/978-3-030-34461-0_38

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Abstract

Hypoxic ischemic encephalopathy (HIE) is a significant cause of death and neurological disability in newborns. Therapeutic hypothermia at 33.5°C is one of the most common treatments in HIE and generally improves outcome; however 45-55% of injuries still result in death or severe neurodevelopmental disability. We have developed a systems biology model of cerebral oxygen transport and metabolism to model the impact of hypothermia on the piglet brain (the neonatal preclinical animal model) tissue physiology. This computational model is an extension of the BrainSignals model of the adult brain. The model predicts that during hypothermia there is a 5.1% decrease in cerebral metabolism, 1.1% decrease in blood flow and 2.3% increase in cerebral tissue oxygenation saturation. The model can be used to simulate effects of hypothermia on the brain and to help interpret bedside recordings.

Highlights

Hypoxic-ischaemic encephalopathy (HIE), often resulting from intrapartum hypoxic-ischemic (HI) injury, is a significant cause of death and morbidity
We present a new systems biology model of the piglet brain, a common animal model for the human neonatal brain, which incorporates temperature effects in the brain tissue physiology
We have expanded an existing systems biology model of the piglet brain physiology to include the impact of hypothermia

Summary

Introduction

Hypoxic-ischaemic encephalopathy (HIE), often resulting from intrapartum hypoxic-ischemic (HI) injury, is a significant cause of death and morbidity. Somewhere between 700,000 deaths amongst neonates can be attributed to HIE alone [1]. Following neonatal HI injury or birth asphyxia, infants are treated with therapeutic hypothermia at a temperature of 33.5 °C, as well as a variety of medications such as morphine and atracurium [2]. 45–55% of cases treated with hypothermia end with death or moderate to severe neurodevelopmental disability [1, 3]. The brain of neonates undergoing hypothermia treatment is monitored through a variety of methods such as electro-encephalography (EEG) [4] and. Ryu et al (eds.), Oxygen Transport to Tissue XLI, Advances in Experimental

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