DEVELOPING A LIST OF POTENTIAL CLINICALLY SIGNIFICANT DRUG - DRUG INTERACTIONS AT FAMILY MEDICINE CLINIC

Abstract

Objectives: To investigate the prevalence of potential DDIs in prescriptions of outpatients and to develop a list of potential clinically significant drug-drug interactions (DDIs) at Family Medicine Clinic. Materials and Method: The construction of the list was based on the consensus of four drug interaction compendia. A cross-sectional descriptive study method was used with 3208 outpatient prescriptions from October 1, 2019 to December 31, 2019 to detect the interactions which appeared on the developed list. Results: The list of 14 clinically important drug interactions was developed. The rate of occurrence of these interactions in the outpatient prescriptions is 0,7%. The drugs involved were amlodipine, simvastatin, prednisolone, metformin, cefuroxime pantoprazole. Age, the number of diagnosed diseases and the number of drugs prescribed were associated with the risk of having potential drug-drug interactions. Conclusion: Analysis of prescription data found that some potential DDIs were identified. Clinical pharmacology should be enhanced to minimize these interactions and ensure proper, safe and effective drug use. Key words: Drug interaction, clinical pharmacist, Family medicine clinic