Abstract
The meiotic spindle aligns and segregates chromosomes during meiosis, and its disruption contributes to aneuploidy. The presence of birefringent spindles in human eggs predicts higher rates of fertilization, embryo development, and pregnancy. Even brief cooling causes spindle disassembly, and egg freezing results in complete depolymerization of meiotic spindles. Current methods of egg freezing are inefficient, with less than 50% survival after thawing. Nearly four decades ago, deuterium oxide (D2O) was shown to stabilize spindles in marine species, and recently we demonstrated that D2O stabilizes spindles during cooling in mouse eggs.
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