Abstract

We report the proton-decoupled deuterium NMR study of labelled diastereomers with remote stereogenic carbons dissolved in various mixtures of poly-γ-benzyl- l-glutamate (PBLG) and poly-γ-benzyl- d-glutamate (PBDG) liquid crystalline solutions. The evolution of quadrupolar splitting as well as the diastereomeric and the enantiomeric discrimination versus the proportion of PBLG and PBDG in the liquid crystalline phase is studied. It is shown that racemic liquid crystalline solutions of PBLG and PBDG may be used to measure diastereomeric excess ( de). Thereafter the spectrum in PBLG solution allows for measuring the enantiomeric excess ( ee) of each diastereomer. These first results suggest substantial prospects in the field of the analysis of diastereomers with remote stereogenic carbons.

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