Deuteration as a Tool for Enhancing the Half-Life of Drug

Abstract

The aim of the article is that deuteration of any compounds leads to the enhancement of metabolic activity.The substitution of Carbon-Hydrogen bond by Carbon –Deutrieum help for enhancing pharmacokinetic profile of the drug. Since CD bond is ten time more tough to C-H bond .Nowadays, many drug molecules are deuterated to increase the residence time of the drug as well as diminution the metabolism of the drug.Deuterated drugs also finds various therapeutic applications.The deuterated drugs is also approved by Food and Drug Administration. The deuteration helps in increasing the dwell time of the drug and reducing frequency of dosing