Abstract
The aim of this study was to investigate effects of detraining on mRNA expression of neuroplasticity-related factors in hippocampus and spatial perception in ovariectomized rats. Twenty five-week-old Sprague Dawley female rats were assigned to three groups(n=12): normal control group(CON), ovariectomized control group(OVX+CON), and ovariectomized treadmill exercise group(OVX+TE). The ovariectomized exercise group performed 12 weeks treadmill exercise and then 12 weeks detraining. After 12 weeks of detraining, BDNF mRNA, IGF-1 mRNA expression in the hippocampus were significantly increased in ovariectomized treadmill exercise group compared with ovariectomized control group. However, VEGF mRNA expression was non significantly increased in ovariectomized tredmill exercise group compared with ovariectomized control group. Escape latency was significantly decreased in ovariectomized treadmill exercise group compared with ovariectomized control group. These results suggest that l2 weeks detraining can result in loss of functional capacity in ovariectomized rats’hippocampus and its effectiveness is still preserved after detraining.
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