Abstract
The detoxification of pyrogens by boiling with a low concentration of hydrogen peroxide has been found applicable to water for injection, normal saline solution, and dextrose and sodium chloride injection. Excess peroxide is decomposed with manganese dioxide, or in the case of dextrose-saline, by activated charcoal. Selas candle filtration removes the decomposing agent. The method produces no significant alteration in the composition of the injection fluids.
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