Abstract
Submit Manuscript | http://medcraveonline.com Other drugs, such as marijuana, have less intense withdrawal effects and risks due to being less addictive. While marijuana is now recognized to cause withdrawal in addicted users, it does not appear to trigger intense withdrawal requiring detox. Acute drug withdrawal produces excess stimulation of glutamate receptors, which increases the rate of nerve all firing to levels above a healthy range. Excessive glutamate excitability can produce free radicals, which can trigger a cascade of events that can lend to neuronal cell death. This cascade of events can be interrupted if the excessive glutamate activity can be decreased. Klonopin tapers stimulate gaba receptors inhibitory effects to lower the excessive glutamate receptors activity. The result is to try to restore balance between the inhibitory effects of gaba, and the excitatory effects of glutamate, to reduce the rate of nerve cell bring back towards a normal range, and prevent neuronal cell death.
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