Abstract
Glucosidases are a group of enzymes responsible of the glycosidic bond cleavage with different specificities depending on the number of monosaccharides, the position of cleavage, and the configuration of the hydroxy groups in their substrates. In particular, inhibitors of α-1,4-glucosidases have generated great interest as potential therapeutic agents for the treatment of type II diabetes (e.g., miglitol (N-2-hydroxyethyl-1-deoxynojirimycin), Glyset, Diastabol, Glucobay),1, 2 obesity,3 hepatitis B and C4, 5 and other viral diseases,6 and cancer.7
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