Determining the extent of osteotomy in patients with medication-related osteonecrosis of the jaw of the mandible: What are the factors for poor prognosis?

Abstract

Medication-related osteonecrosis of the jaw (MRONJ) is known to be one of the adverse events of antiresorptive drugs such as bisphosphonates and denosumab, but the mechanisms and treatment methods of MRONJ have not been established. It is necessary to perform MRONJ therapy without interfering with the treatment of underlying diseases such as osteoporosis and bone metastasis of malignant tumors.