Abstract
The absolute configuration of secondary alcohols can be determined by NOE between the diastereotopic protons of the lactam and the protons of the alcohol moieties in some 1-(alkoxymethyl)-methyl-2-pyrrolidone-5-carboxylate derivatives. Two simple methods based on conformational analysis and 1H NMR data have been developed. The main conformer, in all cases, was established by means of MM, semi-empirical, and ab initio calculations.
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