Abstract
The present study was conducted as an attempt to treat secondary hydatid disease in white mice strain Balb/c by immunohistoflourescent (IHF) staining technique. For this purpose, the mice were infected with hydatid cysts and treatment was done by oxfendazole (OFZ) at a concentration of 30 mg/kg, praziquantel (PZQ) at a concentration of 40 mg/kg and albendazole (ABZ) at a concentration of 10 mg/kg of body weight. Each drug was given weekly for four months and the same concentrations as above. The results showed that the highest treatment efficiency was in case of OFZ + PZQ treated mice, while the groups treated with OFZ, OFZ + ABZ and ABZ + PZQ showed less treatment efficiency, respectively. The IHF staining technique was used to determine the cytokinesis of TGF-β3 in the spleen and liver of experimental mice. For this reason, OFZ is considered as one of the most promising chemotherapies used in the treatment of hydatid cysts.
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