Abstract
Asimple and rapid high-performance liquid chromatography (HPLC) method with tandem mass spectrometry (TMS) detectoin has been developed for the determination of amlodipine in blood plasma. The HPLC system is coupled to a TMS detector via an electrospray ionization (ESI) interface in the positive-ion mode. The plasma samples were extracted either with a diethylether:hexane (8:2, v/v) mixture of by means of solid-phase extraction with Oasis HLB 1-cc cartridges (Waters, USA). The analytes were chromatographed under reversed-phase conditions on a Zorbax 300 SB-C18 column. The proposed HPLC/TMS procedure was successfully used for the study of the clinical pharmacokinetics of amlodipine and other calcium-channel blockers.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
