Determination the level of the alpha retinoid X receptor in the patients with chronic plaque psoriasis in the Iraq and its relation with disease severity

Abstract

The presence of the higher level of the alpha RXR is necessary because the VDR cannot bind on the DNA and this attributed to the VDR has short DNA binding hinge, when the alpha RXR has abnormality in its structure or it may inert this will be lead to the dimishimg the role of both calcitriol and VDR in decreasing the disease intensity and therby increase its comorbidities hyperproliferation among these group. The RXR are superfamily of the nuclear receptor consisted from three subclass include the alpha, beta and gamma members, the alpha RXR is only active members from the RXR family