Abstract
In this study, we assessed the mechanical response of samples from human atherosclerotic diseased media and fibrous cap via uniaxial tensile testing. Results show a pronounced hysteresis phenomenon caused by viscoelasticity during the loading-unloading process. An inverse analysis method with finite element modeling was employed to identify the material parameter values for a viscoelastic anisotropic (VA) constitutive model through matching simulation predictions of load-displacement curves with experimental measurements. The identified material parameter values can be used in simulation studies of diseased human carotid arteries, including investigations of inflation processes associated with stenting or angioplasty.
Highlights
Atherosclerotic plaque rupture is the main cause of acute cardiovascular events such as myocardial infarction and stroke, which cause life-threatening consequences [1, 2]
The data of load vs. stretch ratio from uniaxial tensile tests were used for identification of material parameters of viscoelastic anisotropic (VA) model
The parameter values for samples of diseased media and fibrous cap are shown in Table 1 and Table 2, respectively
Summary
Atherosclerotic plaque rupture is the main cause of acute cardiovascular events such as myocardial infarction and stroke, which cause life-threatening consequences [1, 2]. Plaque rupture is a complicated process involving interactions among the arterial wall, blood pressure, flow-induced shear stress on the fibrous cap, and clinical interventions (stenting and angioplasty). Finite element modeling has been used in the analysis of the fibrous cap failure phenomenon to evaluate stress, strain and damage and to assess the vulnerability of the plaque tissue under supraphysiological expansion [3]. Numerical predictions of the mechanical behavior of plaque tissue are dependent on the availability of material properties, including viscoelastic properties. The instantaneous maximum stresses inside the plaque tissue are governed by viscoelasticity, which tends to reduce the degree of damage under dramatic and large deformation conditions. Given the complicated interaction modalities and the biomechanical behavior of diseased vascular tissues during clinical interventions, there is a pressing need to characterize the viscoelastic properties of atherosclerotic plaque tissues
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