Determination of vancomycin, linezolid and daptomycin resistance among Eenterococcus isolates from a tertiary care hospital

Abstract

The clinical importance of the genus species relates to its intrinsic antibiotic resistance. Synergistic activity of penicillin and aminoglycosides against is preferred treatment. However, Infectious Diseases Society of America (IDSA) recommends usage of linezolid and daptomycin against emerging vancomycin resistant (VRE) isolates. In this study, we sought to measure the prevalence of vancomycin, linezolid and daptomycin resistance in clinical isolates from patients in a tertiary hospital of Western Maharashtra. A total of 363 clinical isolates of species isolated from different clinical samples over the last three years and three months study period were analyzed for antibiotic susceptibility pattern against vancomycin, linezolid and daptomycin. Study demonstrated low prevalence of vancomycin (4.95%) and linezolid resistance (1.10%) among clinical isolates. Combined resistance to vancomycin and linezolid was also noted in few isolates. No daptomycin resistance was detected in this study, however in vitro daptomycin susceptible and vancomycin heteroresistance isolates may not respond to daptomycin monotherapy. Our study, demonstrated relatively low prevalence of vancomycin and linezolid resistance, but emergence of combined newer drug resistance in species is cause of concern and reiterates the importance of importance of judicious use of antibiotics.