Abstract
In this study, the nanoComposite Silica Perchloric Acid Poly (2-Methyl Aniline) (NSPPMA) was synthesized under the solvent-free condition and used as modifier in preparation of chemically modified electrode (CME). The effect of the composition of carbon paste electrode on its voltammograms were evaluated in basic solution with 5.0 × 105 M Trp. It was found that addition of NSPPMA to the carbon paste would generate the peak current of Trp because of its catalytic effect on redox process. The best analytical response was obtained at pH 12.0. The anodic peak currents were proportional to Trp concentrations in the range of 2.5 × 109 5.0 × 10-4 M under the optimized experimental conditions. The detection limit was 1.7 × 10-10 M. The correlation of the peak currents against v1/2 (v is the scan rate) is linear. The proposed method was applied to the determination of Trp in pharmaceuticals formulations successfully.
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