Abstract
A new chemiluminescence method combined with flow injection analysis was developed for the determination of triprolidine hydrochloride. It was based upon the significant enhancing effect of triprolidine hydrochloride on the chemiluminescence reaction of N-bromosuccinimide with luminol in presence of gold nanoparticles as a catalyzer. Under the optimum conditions, the relative chemiluminescence intensity was linearly related to the concentration of triprolidine hydrochloride in the range of 1.0–750.0 µg/L. The detection limit (3s b/S) was 0.2 µg/L and the relative standard deviation was 1.2% for 0.1 mg/L triprolidine hydrochloride solution (n = 11). The method was applied to the determination of triprolidine hydrochloride in capsules and the study of interactions of triprolidine hydrochloride with two serum albumins, bovine serum albumin and human serum albumin. A discussion on the possible chemiluminescence reaction mechanism was also undertaken.
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