Abstract
The differential pulse voltammetric (DPV) determination of trimebutine (TMB) was achieved at a glassy carbon electrode in acetonitrile/0.1 M LiClO 4. Trimebutine gave two irreversible, diffusion controlled peaks at 740 and 1318 mV versus Ag/AgCl reference electrode, respectively. The second oxidation peak was used to determine trimebutine concentrations in the range 1–50 μg ml −1 with a detection limit (3σm) of 0.3 μg ml −1. Precision of the method (RSD, n = 6) within- and between-days obtained from six determinations at 5 μg ml −1 was found to be 0.7 and 1.1%, respectively. The method was successfully applied to the quantitation of TMB in granule dosage form (Debridat ®) and recoveries between 98.4 and 101% were obtained. Excipients did not interfere with the assay and the results agreed well with those determined by previously established HPLC method.
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