Abstract

A strong correlation was found between vinyl chloride concentrations at working places and the increased excretion of thiodiglycolic acid of 18 exposed workers. The mean air concentration of vinyl chloride was calculated referring to personal exposure. The values obtained were in the range of 0,14–7,0 ppm. The excretion of thiodiglycolic acid — measured by GC-MS analysis — amounted to 0,3 – 4,0 mg/L. It could be demonstrated that significant increases of the metabolite excretion occur even at VC-concentrations below 5 ppm.

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