Abstract
The article is devoted to the results of determining the residual amounts of active ingredients of the medicinal product for veterinary use - MONISEN® forte - in the organs and tissues of sheep. MONISEN® forte is a solution for oral and parenteral use, the active ingredients include praziquantel and ivermectin. MONIZEN® forte is used for prophylactic and therapeutic purposes in small ruminants with cestodoses, nematodes of the lungs and gastrointestinal tract, trematodoses, estrosis, psoroptosis, chorioptosis, sarcoptosis, ixodidosis, sifunculatosis, and also melicophagoses, arachinoses, and biliary tract. Carrying out this study is mandatory for the introduction of the drug into wide industrial practice. As a result of the studies, the terms of slaughter of small ruminants after the use of the drug Monizen® forte were established. It is advisable to slaughter sheep for meat 35 days after the last use of the drug.
Highlights
Livestock is an important sector of the country's national economy, which is a source of production such products as wool, meat, milk
To study the dynamics of elimination of residual amounts of ivermectin and praziquantel, 12 sheep were injected with the drug MONIZEN® forte twice, subcutaneously at a therapeutic dose of 1 ml / kg of animal weight
Calibration results for ivermectin and praziquantel are shown in figs. 3, 4
Summary
Livestock is an important sector of the country's national economy, which is a source of production such products as wool, meat, milk. It is metabolized in the liver by oxidative processes, excreted mainly in the feces. Praziquantel is metabolized in the liver by CYP3A enzymes to metabolites, the activity of which is not known It is excreted mainly in the urine [3, 5,6,7]. The work on testing the drug MONIZEN® forte for parasitic diseases of sheep was carried out on the farm on 460 lambs weighing 25-30 kg with a high infection with nematodes, cestodes and larvae of Oestrus ovis. We highlight the results of the determination of the residual amounts of active substances in the organs and tissues of sheep and the establishment of the waiting period
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
