DETERMINATION OF THE SENSITIVITY OF DERMATOMYCOSIS CAUSES TO FUNGICIDES

Abstract

A microbiological study of the affected areas of the skin of dogs and cats was carried out for the detection of microscopic fungi. The following microscopic fungi were isolated from the pathological material: Candida spp., Aspergillus brasiliensis, Epidermophyton spp., Microsporum spp., Mucor spp., Trichophyton spp., Mallasseria spp., Sporotrich spp. Isolated microscopic fungi of the genus Malassezia spp. belong to the superficial mycoses (keratomycoses) and affect the surface layers of the skin and fur. Epidermatophytes: Trichophyton spp., Epidermophyton spp., Microsporum spp. affect the epidermis, skin, and coat. In addition, opportunistic fungi of the genus Aspergillus brasiliensis were found in the studied samples. It was established that the sensitivity of fungi isolated from the affected areas of the skin of dogs and cats to a 1% solution of ketonazole and clotrimazole is different. In particular, a 1% solution of ketonazole showed significantly higher activity compared to a 1% solution of clotrimazole. Thus, when determining the fungicidal effect of ketonazole, the growth retardation zone of the dermatophyte Trichophyton spp. was 34.3±0.6 mm, and the 1% clotrimazole solution was 21.3±0.3 mm. Ketonazol also showed higher fungicidal activity against the microscopic fungi Aspergillus brasiliensis and Candida spp., compared to clotrimazole. Thus, the activity of ketonazole was, respectively, 55.7 and 48.4% higher compared to clotrimazole. Clotrimazole showed the lowest fungicidal effect on Aspergillus brasiliensis, Mallasseria spp., Mucor spp., and Epidermophyton spp., the growth retardation zones of microscopic fungi were, respectively, 14.3±0.3, 14.3±0.6, 14.6± 0.6 and 16.6±0.3 mm.