Determination of the relative and absolute stereochemistry of a potent and α 1A-selective adrenoceptor antagonist

Abstract

The binding affinities and selectivities of antagonists 1– 4 for the α 1A-adrenoceptor are dependent on the stereochemical orientation of the groups at the C-4 and C-5 positions of the oxazolidinone ring. The unambiguous assignment of the relative and absolute configurations of the diastereomers of SNAP 7915 ( 1 ) is reported.