Abstract
AbstractSpectrophotometric pKa determinations of methyl derivatives of Nα‐acetyl‐4‐nitrohistidine methyl ester 1 have been used to determine the position of the tautomeric equilibrium of 1. The N1‐H tautomer is the predominant form with an equilibrium constant KT of 48.The conclusion is supported qualitatively by the study of 1H‐nmr and 13C‐nmr chemical shifts of the imidazole ring atoms and their changes from neutral to acidic media.
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