Abstract
Abstract Biopterin, in its reduced form, is a cofactor to the enzymes catalyzing the rate-limiting reactions in the synthesis of both the catecholamines and serotonin. It has been suggested that it may serve a role in the regulation of these neurotransmitters. Altered biopterin concentrations have also been reported in various neural disorders. In this report, we describe a method using liquid chromatography/electrochemistry to quantitate both the oxidized and reduced forms of biopterin in mouse tissue samples. This method employs a dual-electrode amperometric detector in the parallel-adjacent configuration. Subpicomole detection limits were achieved for all oxidation states.
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