Abstract
ABSTRACT: The anti‐Listeria monocytogenes effects of 8 phenolic compounds, carnosol, carnosic acid, 12‐methoxy carnosic, ferulic and caffeic acid, rosmarinic acid, luteolin and luteolin‐7‐glucoside were evaluated with a Plackett and Burman design in mixtures mimicking the phenolic composition of rosemary extract without essential oils. At 30°C carnosic acid was the most efficient compound during 24 h, whereas luteolin became more active after 72 h. The antibacterial effect of pure carnosic acid was modeled under a range of different pH and NaCl concentration, using a Doehlert design. Under moderately acidified conditions, carnosic acid displayed a bactericidal effect at low concentration (5.5 μg/ml). Its activity was not greatly influenced by NaCl.
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