Abstract
The need for dextran fractions with a narrow molecular-weight distribution for clinical use is well known. The definition of such material has significantly improved by the use of gel permeation chromatography (GPC) techniques. However, an internationally accepted standard method of analysis giving accurate and reproducible results in different laboratories has yet to be defined. This paper reviews the GPC packings that can be or have been used for determining the molecular weight distribution of dextran polymers. The application of GPC to the determination of the molecular weight of dextrans on TSK PW type columns is described and its accuracy and reproducibility are discussed. This material appears to meet the criteria required for a standard method.
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