Determination of the Material Parameters in the Holzapfel-Gasser-Ogden Constitutive Model for Simulation of Age-Dependent Material Nonlinear Behavior for Aortic Wall Tissue under Uniaxial Tension

Up Huh,Chung-Won Lee,Chi-Seung Lee,Chan-Hee Song,Dong-Man Ryu,Ji-Hun You

doi:10.3390/app9142851

Up Huh, Chung-Won Lee + Show 4 more

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https://doi.org/10.3390/app9142851

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Abstract

In this study, computational simulations and experiments were performed to investigate the mechanical behavior of the aorta wall because of the increasing occurrences of aorta-related diseases. The study focused on the deformation and strength of porcine and healthy human abdominal aortic tissues under uniaxial tensile loading. The experiments for the mechanical behavior of the arterial tissue were conducted using a uniaxial tensile test apparatus to validate the simulation results. In addition, the strength and stretching of the tissues in the abdominal aorta of a healthy human as a function of age were investigated based on the uniaxial tensile tests. Moreover, computational simulations using the ABAQUS finite element analysis program were conducted on the experimental scenarios based on age, and the Holzapfel–Gasser–Ogden (HGO) model was applied during the simulation. The material parameters and formulae to be used in the HGO model were proposed to identify the failure stress and stretch correlation with age.

Highlights

The aorta is the primary artery through which blood leaves the human heart before it flows through the entire human body, and it is typically divided into several sections based on anatomical source, as shown in Figure 1 [1,2,3,4]
In this study, the material parameters of the HGO model [24] were adjusted with a simulation test based on the stress–stretch curve of the tissues the HGO model [24] were adjusted with a simulation test based on the stress–stretch curve of the in the porcine abdominal aorta
The tissue specimens in the healthy human abdominal simulating aortic disease and the experimental results based on age obtained from the uniaxial tensile aortaperformed were extracted from cadavers

Summary

Introduction

The aorta is the primary artery through which blood leaves the human heart before it flows through the entire human body, and it is typically divided into several sections based on anatomical source, as shown in Figure 1 [1,2,3,4]. Based on the anatomical compartment, it is categorized as the thoracic aorta from the heart to the diaphragm and the abdominal aorta from the diaphragm to the bifurcation of the aorta, respectively. Another classification method classifies the aorta according to its route and blood flow direction. The aorta ends at a bifurcation, which is divided into two main blood vessels: the common iliac arteries and a smaller midline vessel, the median sacral artery [5]

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