Abstract
Lipophilicity is an extremely important molecular property which has frequently been used in QSAR studies and in the design of new drugs with the required biological activity. Determination of lipophilicity is based on partition of a neutral substance between aqueous and non-aqueous phases under equilibrium conditions; these conditions represent the phase boundary in biological membranes. Lipophilicity is then expressed by the logarithm of the partition coefficient, log P, determined in the reference system n-octanol–water [1]. In addition to the traditional shake-flask method lipophilicity can be determined by chromatographic techniques, especially reversed-phase thinlayer chromatography (RP TLC) [2–5] and high-performance liquid chromatography (RP HPLC) [6, 7]. Determination of lipophilicity by partition chromatography is based on the linear relationship between log k values and φ [%, v/v], the volume fraction of organic solvent in the mobile phase, as described by eq. (1) [4–7]:
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