Abstract
Psychotropic drugs have been chromatographed on RP-18-HPTLC plates with mobile phases containing water, an organic modifier (methanol, dioxane, acetone, acetonitrile or tetrahydrofuran), and ion-pair reagents or ammonia. R F was measured for different concentrations of organic modifier. Relationships between solute retention and modifier concentration were described by the Soczewinski-Wachtmeister and Schoenmaker equations. The equations were used to determine R MW by the extrapolation method. Calculated values of R MW or C were correlated with log P values for the drugs, estimated by use of software. Significant correlations between the intercept ( R MW ) and slope ( S ) of the linear equations were also calculated. Chromatographic systems for which the R MW values obtained were close to calculated log P values can be used for determination of the lipophilicity of basic drugs.
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