Abstract
The purpose of the studywas to assess the state of the pancreas in children, taking into account the indicators of pancreatic elastase of blood serum and feces.Materials and methods.A study of pancreatic elastase was carried out in 115 children aged 7-15 years with combined gastroduodenal and biliary pathology.Results.In a comprehensive assessment of the structural and functional state of the pancreas, it was found that in 26.5% of cases there were functional and 45.2% structural changes: chronic pancreatitis - 9.6% of patients, recurrent pancreatitis - 9.9%, reactive pancreatitis - 25.7% of children, dysfunctional disorders - 26.5% of patients. Findings. The studied method has 100% sensitivity and 98% specificity in the differential diagnosis of functional and structural changes in the pancreas. The coprological test allows a quantitative determination of the elastase-1 level, reflecting the degree of pancreatic insufficiency.Conclusion.Using this test for quantitative determination in serum provides an opportunity to assess the level of enzymemia in reactive pancreatitis. In accordance with modern concepts, pancreatic elastase can be considered as the “gold standard” for diagnosing chronic pancreatitis, a marker for the exocrine function of the pancreatic gland (scatological test) and as an indicator of reactive pancreatitis (definition of serum elastase-1).
Highlights
Using this test for quantitative determination in serum provides an opportunity to assess the level of enzymemia in reactive pancreatitis
In accordance with modern concepts, pancreatic elastase can be considered as the “gold standard” for diagnosing chronic pancreatitis, a marker for the exocrine function of the pancreatic gland and as an indicator of reactive pancreatitis
В соответствии с современными представлениями панкреатическая эластаза может рассматриваться в качестве «золотого стандарта» диагностики хронического панкреатита, маркера экзокринной функции панкреатической железы (копрологический тест) и как показателя реактивного панкреатита (определение сывороточной эластазы-1)
Summary
Определение панкреатической эластазы в сыворотке проводят у пациентов с абдоминальными болями с целью диагностики острого панкреатита. Что активность эластазы 1 повышается в крови при остром и обострении хронического панкреатита раньше, чем уровень других ферментов – на субклинической стадии. Целью настоящей работы явилась оценка состояния поджелудочной железы у детей с учетом показателей панкреатической эластазы сыворотки крови и кала. При этом в дуоденальном содержимом этой группы пациентов наблюдалось преимущественно снижение активности ферментов (не менее двух) в стимулированную фазу, либо обтурационный тип панкреатической секреции.
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