Abstract
Dr. Burcin Tezcanli Kaymaz, Ege Universitesi Tip Fakultesi Hastanesi, Bornova 35100 Izmir Turkiye, Tel. 0232 390 22 60 Email. bt1980@gmail.com Gelis Tarihi: 12.04.2013 • Kabul Tarihi: 18.07.2013 ABSTRACT AIM: Capsaicin, an ingredient of red chili pepper consumed as spice throughout the world is defi ned as “double-edged sword” agent for having possible tumorigenicity/genotoxicity properties, for being antagonist to carcinogens/mutagens for inducing tumor cell apoptosis. However, reasons of capsaicin induced leukemic cell apoptosis are investigated. In this study, following capsaicin treatment to acute lymphoblastic leukemia cell line CCRF-CEM, detecting apoptosis; determining gene expression profi les of JAK/STAT signaling pathway members STAT3, STAT5A,-5B, JAK2,IL-6 mRNA levels and clarifying possible molecular effect mechanism of capsaicin were aimed.
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