Determination of the frequency and distribution of vascular and parenchymal amyloid with polyclonal and N-terminalspecific PrP antibodies in scrapie-affected sheep and mice

Abstract

Brains from 17 histopathologically confirmed cases of scrapie, five of which had congophilic vascular amyloid, were stained immunohistochemically for prion protein (PrP) using a polyclonal antibody. Two clinically suspect but...