Abstract
The formation of thromboxane B 2 (TxB 2), 12L-hydroxy-5,8,10 heptadecatrienoic acid (HETE) and 12L-hydroxy-5,8,10,14 eicosatrienoic acid (HETE) was determined in the platelets of normal human males and of patients with disorders in which an abnormal platelet aggregation occurs. Platelets were labelled with [1- 14C] arachidonic acid. After aggregation and extraction the metabolites were separated by TLC and determined. In the platelets of normal males, TxB 2 values were in the range 4.4–12.4%, expressed as a percentage of total radioactivity. Curves were constructed for the following ratios: TxB 2:HHT, TxB 2:HETE and (TxB 2 + HHT):HETE. These ratios were fairly constani. A comparison was made with the ratios obtained in the platelets of a small number of patients with either an enhanced or a diminished aggregation.
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