Abstract
An instrumental neutron activation analysis (INAA) technique, based on the19F(n,λ)20F reaction, has been development for the determination of fluoride in bone. The purpose was to study fluoride distribution in different kinds of bone samples using a rabbit model. The rationale for the study stems from the posible correlation between fluoride in bone and osteoporosis. The sodium concentration in the bone was used to correct the20F peak area for the23F(n,α)20F contribution. Two secondary standards, teflon tape and teflon coated dacron line, were used to quantify fluoride concentration. They proved to be stable and consistent with respect to their fluoride concentration. Bone specimens from 10 sites and two tooth samples were analyzed for fluoride. Fluoride concentration ranged from 305 ppm in the tibia long bone to 585 ppm in the humerus trochanter end and the magnitude of fluoride concentration levels is age depdentent. The detection limit of the fluoride is approximately 5 ppm using a 100 mg bone sample.
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