Abstract
A new analytical procedure has been developed for the determination of the enantiomeric purity of amphetamine samples. It is based on the derivatization of amphetamine with 2,4-dinitrofluorobenzene and a subsequent measurement of the anisotropy factor by dual (CD/UV) spectroscopy. This factor depends on the enantiomeric composition and does not depend on the concentration, a feature that eliminates the systematic errors caused by the sample preparations such as dilution, weighing, etc. The main advantage of the approach is the fact that the new synthetized derivative can be measured in the visible wavelength region with significantly better sensitivity than the underivatized amphetamine. The applicability of the procedure is demonstrated by results obtained by analysis of model materials containing amphetamine enantiomers at different ratios.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
