Determination of the effect of an aqueous seed extract of sesbania sesban (l) merr. on the levels of non-enzymic antioxidant status in experimental animals

Abstract

This study investigates the effect of aqueous extract of seeds of Sesbania Sesban (L) Merr. on the levels of non-enzymatic antioxidants such as reduced glutathione and vitamin-C in different organs of experimental animals subjected to inflammation with a standard drug. The experimental animals were induced inflammation with administration of a standard inflammatory drug, Carrageenan and two different concentrations of plant extract viz.150mg/kg body weight and 300mg/kg body weight of experimental animals were administered through oral mode one hour prior to Carrageenan induction. After induction and treatment, the organs such as spleen, thymus and hind paw were removed and was evaluated to test the effect of plant extract on non-enzymatic antioxidant levels in two experimental group of animals from the homogenate sample. The values obtained showed the protective effect of the plant extract in enhancing the levels of both the antioxidants in a dose-dependent manner to a significant level.