Abstract
A high-performance liquid chromatographic method for the simultaneous determination of four indolequinazoline alkaloids (carboxyevodiamine, dehydroevodiamine, evodiamine and rutaecarpine) and eight quinolone alkaloids (1-methyl-2-nonyl-4(1H)-quinolone, 1-methyl-2-[(Z)-6-undecenyl]-4(1H)-quinolone, 1-methyl-2-undecyl-4(1H)-quinolone, evocarpine, 1-methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone, dihydroevocarpine, 1-methyl-2-[(Z)-10-pentadecenyl]-4(1H)-quinolone and 1-methyl-2-[(Z)-6-pentadecenyl]-4(1H)-quinolone) in Evodiae Fructus was developed. The method was carried out by using a Capcell C 18 SG-120 column with a gradient solvent system of acetate buffer-acetonitrile-methanol and a UV detector (250 nm), and the contents of the alkaloids in a non-pretreated Evodiae Fructus extract could easily be determined within 40 min. Validation of this method is described.
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