Abstract
Borohydrides and borane complexes have been widely used as selective reducing agents in many chemical apptications. In particular, the pyridine-borane complex (PBC, C 5 H 5 N-BH 3 ) is very stable to hydrolysis and is an attractive reagent for large-scale reductions that are common in the pharmaceutical industry. This report describes a simple, rapid, and reproducible method for quantitating the active hydrogen content in PBC. The method exploits the ease with which Schiff bases are reduced by amine-boranes and uses high-performance liquid chromatography to quantitate the reduction product. The method is not affected by small amounts of extraneous moisture and can be carried out in common glassware
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